Scientific American:
Growing evidence shows that many people can be considered overweight and healthy The new medications, technically known as glucagon-like peptide 1 (GLP-1) receptor agonists, are used to promote substantial weight loss, cause a host of cardiometabolic improvements, and treat type 2 diabetes. (Drugs for the latter include a form of semaglutide sold as Ozempic.) But when a person who had been taking one of these medications stops, the hunger cues it had suppressed come raging back, which causes the weight to return. Other health benefits of the drugs, such as reduced blood pressure, also tend to bounce back after stopping treatment.
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