One of my grandkids has celiac disease and has to follow a lifelong gluten-free diet. The disease tends to cluster in families. Parents and siblings and first-degree relatives with celiac disease have between a 4 and 15 percent chance of developing the disorder. However, the inheritance pattern is unknown. I have no one among my relatives with the condition, but practically I have no blood relatives. This is a strange disease because Jewish diets contain cereals and it has been so for the last four thousand years - since the settling of Eretz Israel. Any mutation preventing the consumption of bread should have been eliminated long ago. Celiac is genetic and related to the CCR gene family, inherited from the Neanderthalers. We also inherited from them the red hair gene. It is a mystery.
Thursday, April 22, 2021
The Celiac Mystery
One of my grandkids has celiac disease and has to follow a lifelong gluten-free diet. The disease tends to cluster in families. Parents and siblings and first-degree relatives with celiac disease have between a 4 and 15 percent chance of developing the disorder. However, the inheritance pattern is unknown. I have no one among my relatives with the condition, but practically I have no blood relatives. This is a strange disease because Jewish diets contain cereals and it has been so for the last four thousand years - since the settling of Eretz Israel. Any mutation preventing the consumption of bread should have been eliminated long ago. Celiac is genetic and related to the CCR gene family, inherited from the Neanderthalers. We also inherited from them the red hair gene. It is a mystery.
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